Glutamate Regulates Kainate-binding Protein Expression in Cultured Chick Bergmann Glia through an Activator Protein-1 Binding Site

Silver Resistance In Acinetobacter baumannii BL54 Occurs Through Binding to a Ag-Binding Protein

The mechanism of plasmid mediated silver (Ag) resistance was investigated in Acinetobacter baumanniiBL54. The intracellular accumulation of Ag in both original strain BL54 and Escherichia coli K12transconjugant containing plasmid pUPI276 began immediately and reached a maximum within 60 minutes.This initial accumulation was followed by net loss of Ag which reached a maximum wi...

Heparin Decreases Activator Protein-1 Binding

Heparin is a potent inhibitor of the proliferation and migration of vascular smooth muscle cells. This agent selectively inhibits the transcription of tissue-type plasminogen activator and interstitial collagenase, probably by decreasing the binding of activator protein-1 (AP-1) to phorbol ester-responsive elements in the promoters of these genes. Decreased AP-1 binding is not due to a direct i...

Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy

Allosteric switch regulates protein-protein binding through collective motion.

Many biological processes depend on allosteric communication between different parts of a protein, but the role of internal protein motion in propagating signals through the structure remains largely unknown. Through an experimental and computational analysis of the ground state dynamics in ubiquitin, we identify a collective global motion that is specifically linked to a conformational switch ...

Study of PKA binding sites in cAMP-signaling pathway using structural protein-protein interaction networks

Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...